In Vivo Microelectrode Arrays for Detecting Multi-Region Epileptic Activities in the Hippocampus in the Latent Period of Rat Model of Temporal Lobe Epilepsy

Temporal lobe epilepsy (TLE) is a form of refractory focal epilepsy, which includes latent period and chronic period. Microelectrode arrays capable multi-region detection neural activities are important for accurately identifying the epileptic focus pathogenesis mechanism in TLE. Here, we fabricated multi-shank MEAs to detect DG, hilus, CA3, CA1 TLE rat model. In rats, seizures were induced changes detected. The results showed that spread from hilus CA3 other areas. Furthermore, interneurons more excited than principal cells exhibited rhythmic oscillations at approximately 15 Hz grand mal seizures. addition, power spectral density (PSD) spikes local field potentials (LFPs) synchronized frequency domain alpha band (9–15 Hz) after induction suggest have advantages simultaneous precise multiple subregions hippocampus. Our promote study cellular mechanisms during period, provides an basis diagnosis lesion